ea0026p370 | Signal transduction | ECE2011
Chiellini G
, Erba P
, Carnicelli V
, Ghelardoni S
, Frascarelli S
, Zucchi R
Introduction: 3-Iodothyronamine (T1AM) is a novel endogenous relative of thyroid hormone able to interact with specific G protein-coupled receptors, known as trace amine-associated receptors (TAAR). Metabolic, endocrine and cardiac effects of exogenous T1AM have been reported.Methods: We synthesized radiolabelled T1AM, [125I]-T1AM, and explored its distribution in different mouse organs after injection in the tail vein. The specificity of [<su...